Sunday, July 26, 2009

[HapMap project]

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Haplotype map is the basis of SNP association studies in two aspects. One is to understand how SNPs are organized on chromosomes, thereby helping researchers to select tag SNPs to be examined. The other is to explore the presence of "hidden SNP" by haplotype analyses that is really associated with the disease. Although it is very difficult to forecast the future of SNP studies, the final and ideal methodology should be high--throughput whole genome sequencing with low price. At such stage, data mining technique will be very important since huge amount of genotype data should be handled and analyzed.

PMID: 19507494 [PubMed - indexed for MEDLINE]

(source URL, Via PubMed: SNP CNV last2.)