Tuesday, July 7, 2009

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

The effect of genetic mutation on phenotype is of significant interest in genetics. The type of genetic mutation that causes a single amino acid substitution (AAS) in a protein sequence is called a non-synonymous single nucleotide polymorphism (nsSNP). An nsSNP could potentially affect the function.

(source URL, Via Nature Protocols.)