Saturday, May 1, 2010

Dynamic view of the MS genome - source: 'The Scientist '

The study, published this week in Nature, included three pairs of identical twins, two female pairs and one male, in which one had multiple sclerosis (MS) and the other did not. No one knows the cause of MS. Some evidence points to a genetic root of the neurodegenerative disorder: In thirty percent of identical twins where one has MS, so does the other. Changes to the human leukocyte antigen (HLA) region of chromosome 6 has been linked to an increased susceptibility to MS, and 6 genome-wide association studies implicate 12 other loci in the disease.

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Publication: S.E. Baranzini et al., "Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis," Nature 464(29):1351-6, 2010.

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