Friday, July 23, 2010

GeneBrowser 2: an application to explore and identify common biological traits in a set of genes

Background:
The development of high-throughput laboratorial techniques created a demand for computer-assisted result analysis tools. Many of these techniques return lists of genes whose interpretation requires finding relevant biological roles for the problem in hand. The required information is typically available in public databases, and most of the time, it must be manually retrieved in order to complement the analysis. This is a very time-consuming task that should be automated as much as possible.
Results:
GeneBrowser is a web-based tool that, for a given list of genes, combines data from several public databases with visualization and analysis methods to help identify the most relevant and common biological characteristics. The functionalities provided include: a central point with the most relevant biological information for each inserted gene; a list of the most related papers in PubMed and gene expression studies in ArrayExpress; and an extended approach to functional analysis applied to Gene Ontology, homologies, gene chromosomal localization and pathways.
Conclusions:
GeneBrowser provides a unique entry point to several visualization and analysis methods providing fast and easy analysis of a set of genes. GeneBrowser fills the gap between Web portals that analyse one gene at a time, and functional analysis tools that are limited in scope and usually desktop-based.

(this Post content was reproduced from: http://www.biomedcentral.com/1471-2105/11/389, Via BMC Bioinformatics - Latest articles.)