Sunday, October 17, 2010

QTLminer: identifying genes regulating quantitative traits

Background:
Quantitative trait locus (QTL) mapping identifies genomic regions that likely contain genes regulating a quantitative trait. However, QTL regions may encompass tens to hundreds of genes. To find the most promising candidate genes, the biologist typically collects information about the genes in the QTL region from multiple resources. This process is very laborious and time consuming.
Results:
QTLminer is a bioinformatics tool that automatically performs QTL region analysis. It is available in GeneNetwork and it integrates information such as gene annotation, gene expression and sequence polymorphisms for all the genes within a given genomic interval.
Conclusions:
QTLminer substantially speeds up discovery of the most promising candidate genes within a QTL region.

(this Post content was reproduced from: http://www.biomedcentral.com/1471-2105/11/516, Via BMC Bioinformatics - Latest articles.)