Friday, December 31, 2010

Assemblies: the good, the bad, the ugly

Assemblies: the good, the bad, the ugly: "


Assemblies: the good, the bad, the ugly


Nature Methods 8, 59 (2011). doi:10.1038/nmeth0111-59


Author: Ewan Birney


The low cost of short-read sequencing has motivated the development of de novo assemblies from only short-read data; impressively, assemblies for large mammalian genomes are now available. However, this is still a developing field, and these de novo assemblies have many artifacts, as do all de novo assemblies.


(Via Nature Methods current.)