Monday, July 25, 2011

Genome-wide approaches for cancer gene discovery.

Genome-wide approaches for cancer gene discovery.: Publication Date: 2011 Jul 12 PMID: 21757246
Authors: Lizardi, P. M. - Forloni, M. - Wajapeyee, N.
Journal: Trends Biotechnol

One of the central aims of cancer research is to identify and characterize cancer-causing alterations in cancer genomes. In recent years, unprecedented advances in genome-wide sequencing, functional genomics technologies for RNA interference screens and methods for evaluating three-dimensional chromatin organization in vivo have resulted in important discoveries regarding human cancer. The cancer-causing genes identified from these new genome-wide technologies have also provided opportunities for effective and personalized cancer therapy. In this review, we describe some of the most recent technologies for cancer gene discovery. We also provide specific examples in which these technologies have proven remarkably successful in uncovering important cancer-causing alterations.

post to: CiteULike

(Via Trends in biotechnology.)