Tuesday, October 4, 2011

Fwd: PolyPhen2, MutationTaster, LRT, PhyloP (dbNSFP - Jpopgen)

Other ways to estimate variation effects (recent tools)
dbNSFP - Jpopgen: dbNSFP
The dbNSFP is an integrated database of functional predictions from multiple algorithms for the comprehensive collection of human non-synonymous SNPs (NSs). Its current version (ver 1.1) is based on CCDS version 20090327 and includes a total of 75,931,005 NSs. It compiles prediction scores from four prediction algorithms (SIFT, Polyphen2, LRT and MutationTaster), a conservation score (PhyloP) and other related information.
(please read more on Xiaoming Liu's site: http://sites.google.com/site/jpopgen/dbNSFP)
Citation: Liu X, Jian X, and Boerwinkle E. 2011. dbNSFP: a lightweight database of human non-synonymous SNPs and their functional predictions. Human Mutation. 32:894-899 (PMID:21520341).

(Via Annovar Website.)