Friday, January 6, 2012

Fwd: ART: a next-generation sequencing read simulator

Fwd: please follow footer link
ART: a next-generation sequencing read simulator:

Summary: ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly, and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large sequencing datasets. We currently support all three major commercial next-generation sequencing platforms: Roche’s 454, Illumina’s Solexa, and Applied Biosystems’ SOLiD.

ART also allows the flexibility to use customized read error model parameters and quality profiles.

Availability: Both source and binary software packages are available at http://www.niehs.nih.gov/research/resources/software/art.

Contact: WH at weichun.huang@nih.gov or GTM at gabor.marth@bc.edu.



(Original Post: Bioinformatics - Advance Access.)