Sunday, February 12, 2012

Fwd: Predicting the effects of frameshifting indels

Fwd: please follow footer link
Predicting the effects of frameshifting indels: Each human has approximately 50-280 frameshifting indels, yet their implications are unknown. We created SIFT Indel, a prediction method for frameshifting indels which has 84% accuracy. The percentage of human frameshifting indels predicted to be gene-damaging is negatively correlated with allele frequency. We also show that although the first frameshifting indel in a gene causes loss of function, there is a tendency for the second frameshifting indel to compensate and restore protein function.

SIFT Indel is available at

(Original Post: Genome Biology - Latest Articles.)