Saturday, May 5, 2012

Fwd: BRAT-BW: Efficient and accurate mapping of bisulfite-treated reads

Fwd: please follow footer link
BRAT-BW: Efficient and accurate mapping of bisulfite-treated reads:

Summary: We introduce BRAT-BW, a fast, accurate and memory-efficient tool that maps bisulfite-treated short reads (BS-seq) to a reference genome using the FM-index (Burrows-Wheeler transform). BRAT-BW is significantly more memory efficient and faster on longer reads than current state-of-the-art tools for BS-seq data, without compromising on accuracy. BRAT-BW is a part of a software suite for genome-wide single base-resolution methylation data analysis that supports single and paired-end reads and includes a tool for estimation of methylation level at each cytosine.

Availability: The software is available in the public domain at http://compbio.cs.ucr.edu/brat/

Contact:elenah@cs.ucr.edu



(Original Post: Bioinformatics - Advance Access.)