Saturday, May 5, 2012

Fwd: BreakFusion: Targeted Assembly-based Identification of Gene Fusions in Whole Transcriptome Paired-end Sequencing Data

Fwd: please follow footer link
BreakFusion: Targeted Assembly-based Identification of Gene Fusions in Whole Transcriptome Paired-end Sequencing Data:

Summary: Despite recent progress, computational tools that identify gene fusions from next-generation whole transcriptome sequencing data are often limited in accuracy and scalability. Here we present a software package, BreakFusion that combines the strength of reference alignment followed by read-pair analysis and de novo assembly to achieve a good balance in sensitivity, specificity, and computational efficiency.

Availability:http://bioinformatics.mdanderson.org/main/BreakFusion

Contact:kchen3@mdandesron.org or lding@genome.wustl.edu



(Original Post: Bioinformatics - Advance Access.)