Saturday, May 26, 2012

Fwd: The UEA sRNA Workbench: A Suite of Tools for Analysing and Visualising Next Generation Sequencing microRNA and Small RNA Datasets

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The UEA sRNA Workbench: A Suite of Tools for Analysing and Visualising Next Generation Sequencing microRNA and Small RNA Datasets:

Summary: RNA silencing is a complex, highly conserved mechanism mediated by small RNAs (sRNAs), such as microRNAs (miRNAs), that is known to be involved in a diverse set of biological functions including development, pathogen control, genome maintenance and response to environmental change. Advances in Next Generation Sequencing (NGS) technologies are producing increasingly large numbers of sRNA reads per sample at a fraction of the cost of previous methods. However, many bioinformatics tools do not scale accordingly, are cumbersome, or removed: require extensive bioinformatics support. Replaced with: require extensive support from bioinformatics experts. Therefore, researchers need user-friendly, robust tools, capable of not only processing large sRNA datasets in a reasonable time-frame but presenting the results in an intuitive fashion and visualising sRNA genomic features. Here we present the UEA sRNA Workbench, a suite of tools that is a successor to the web-based UEA sRNA Toolkit, but in downloadable format and with several enhanced and additional features.

Availability: The program and help pages are available at http://srna-workbench.cmp.uea.ac.uk

Contact:vincent.moulton@cmp.uea.ac.uk



(Original Post: Bioinformatics - Advance Access.)