Friday, June 29, 2012

Fwd: PurityEst: estimating purity of human tumor samples using next-generation sequencing data

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PurityEst: estimating purity of human tumor samples using next-generation sequencing data:

Summary: We developed a novel algorithm, PurityEst, to infer the tumor purity level from the allelic differential representation of heterozygous loci with somatic mutations in a human tumor sample with a matched normal tissue using next-generation sequencing data. We applied our tool to a whole cancer genome sequencing data sets and demonstrated the accuracy of PurityEst compared to DNA copy number-based estimation.

Availability: PurityEst has been implemented in PERL and is available at http://odin.mdacc.tmc.edu/~xsu1/PurityEst.html

Contact:xsu1@mdanderson.org



(Original Post: Bioinformatics - Advance Access.)