Friday, June 15, 2012

Fwd: SIFT web server: predicting effects of amino acid substitutions on proteins

Fwd: please follow footer link
SIFT web server: predicting effects of amino acid substitutions on proteins:

The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding variants on protein function. It was first introduced in 2001, with a corresponding website that provides users with predictions on their variants. Since its release, SIFT has become one of the standard tools for characterizing missense variation. We have updated SIFT’s genome-wide prediction tool since our last publication in 2009, and added new features to the insertion/deletion (indel) tool. We also show accuracy metrics on independent data sets. The original developers have hosted the SIFT web server at FHCRC, JCVI and the web server is currently located at BII. The URL is http://sift-dna.org (24 May 2012, date last accessed).

Guide for Using SIFT on Amazon Cloud Service

Many users have had trouble installing SIFT because it relies on old code from BLIMPS and BLAST. We have made a public image of SIFT available on the Amazon cloud so that you can run SIFT yourself, without having to bother with installation.


(Original Post: NAR - Advance Access.)