Friday, July 6, 2012

Fwd: BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data

Fwd: please follow footer link
BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data:

Summary: Despite recent progress, computational tools that identify gene fusions from next-generation whole transcriptome sequencing data are often limited in accuracy and scalability. Here, we present a software package, BreakFusion that combines the strength of reference alignment followed by read-pair analysis and de novo assembly to achieve a good balance in sensitivity, specificity and computational efficiency.

Availability:http://bioinformatics.mdanderson.org/main/BreakFusion

Contact:kchen3@mdanderson.org; lding@genome.wustl.edu

Supplementary information:Supplementary data are available at Bioinformatics online



(Original Post: Bioinformatics - current issue.)