Friday, August 31, 2012

Fwd: Identifying ChIP-seq enrichment using MACS

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Identifying ChIP-seq enrichment using MACS:

Identifying ChIP-seq enrichment using MACS

Nature Protocols 7, 1728 (2012).
doi:10.1038/nprot.2012.101

Authors: Jianxing Feng, Tao Liu, Bo Qin, Yong Zhang & Xiaole Shirley Liu

Model-based analysis of ChIP-seq (MACS) is a computational algorithm that identifies genome-wide locations of transcription/chromatin factor binding or histone modification from ChIP-seq data. MACS consists of four steps: removing redundant reads, adjusting read position, calculating peak enrichment and estimating the empirical false discovery rate (FDR).



(Original Post: Nature Protocols.)