Monday, December 10, 2012

Fwd: Identifying differentially spliced genes from two groups of RNA-seq samples

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Identifying differentially spliced genes from two groups of RNA-seq samples.
Abstract:
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We developed a NB-statistic method that can detect differentially spliced genes between two groups of samples without using a prior knowledge on the annotation of alternative splicing. It does not need to infer isoform structure or to estimate isoform expression. It is a useful method designed for comparing two groups of RNA-seq samples. Besides identifying differentially spliced genes, the method can highlight on the exons that contribute the most to the differential splicing. We developed a software tool called DSGseq for the presented method available at http://bioinfo.au.tsinghua.edu.cn/software/DSGseq.


(Original Post: Gene Article.)