Saturday, June 1, 2013

Fwd: Global Properties and Functional Complexity of Human Gene Regulatory Variation

The Regulome has its own Variome. Snap-shooting Evolution.
Fwd: please follow footer link

Global Properties and Functional Complexity of Human Gene Regulatory Variation: "

by Daniel J. Gaffney


Identification and functional interpretation of gene regulatory variants is a major focus of modern genomics. The application of genetic mapping to molecular and cellular traits has enabled the detection of regulatory variation on genome-wide scales and revealed an enormous diversity of regulatory architecture in humans and other species. In this review I summarise the insights gained and questions raised by a decade of genetic mapping of gene expression variation. I discuss recent extensions of this approach using alternative molecular phenotypes that have revealed some of the biological mechanisms that drive gene expression variation between individuals. Finally, I highlight outstanding problems and future directions for development."

(Via PLOS Genetics.)