Saturday, June 8, 2013

Fwd: NGS++: a library for rapid prototyping of epigenomics software tools

Fwd: please follow footer link

NGS++: a library for rapid prototyping of epigenomics software tools: "

Motivation: The development of computational tools to enable testing and analysis of high throughput-sequencing data is essential to modern genomics research. However, while multiple frameworks have been developed to facilitate access to these tools, comparatively little effort has been made at implementing low level programming libraries to increase the speed and ease of their development.

Results: We propose NGS++, a programming library in C++11 specialized in manipulating both Next-Generation Sequencing (NGS) datasets and genomic information files. This library allows easy integration of new formats and rapid prototyping of new functionalities with a focus on the analysis of genomic regions and features. It offers a powerful, yet versatile and easily extensible interface to read, write and manipulate multiple genomic file formats. By standardizing the internal data structures and presenting a common interface to the data parser, NGS++ offers an effective framework for epigenomics tool development.

Availability: NGS++ was written in C++ using the C++11 standard. It requires minimal efforts to build and is well-documented via a complete docXygen guide, online documentation and tutorials. Source code, tests, code examples and documentation are available via the website at and the github repository at,


(Via Bioinformatics - Advance Access.)