Sunday, December 8, 2013

Fwd: ChromoHub V2: Cancer Genomics

Fwd: please follow footer link

ChromoHub V2: Cancer Genomics: "

Summary: Cancer genomics data produced by next generation sequencing supports the notion that epigenetic mechanisms play a central role in cancer. We have previously developed Chromohub, an open access online interface where users can map chemical, structural and biological data from public repositories on phylogenetic trees of protein families involved in chromatin mediated signaling. Here, we describe a cancer genomics interface that was recently added to Chromohub; the frequency of mutation, amplification, and change in expression of chromatin factors across large cohorts of cancer patients is regularly extracted from The Cancer Genome Atlas and the International Cancer Genome Consortium and can now be mapped on phylogenetic trees of epigenetic protein families. Explorators of chromatin signaling can now easily navigate the cancer genomics landscape of writers, readers and erasers of histone marks, chromatin remodeling complexes, histones and their chaperones.



(Via Bioinformatics - Advance Access.)