Friday, July 4, 2014

Fwd: How Much of the Variation in the Mutation Rate Along the Human Genome Can Be Explained?

Fwd: please follow footer link

How Much of the Variation in the Mutation Rate Along the Human Genome Can Be Explained?: "

It has been recently claimed that it may be possible to predict the rate of de novo mutation of each site in the human genome with a high degree of accuracy (Michaelson et al. (2012) Cell, 151, 1431-1442). We show that this claim is unwarranted. By considering the correlation between the rate of de novo mutation and the predictions from the model of Michaelson et al., we show there could be substantial unexplained variance in the mutation rate. We investigate whether the model of Michaelson et al. captures variation at the single nucleotide level that is not due to simple context. We show that the model captures a substantial fraction of this variation at CpG dinucleotides but fails to explain much of the variation at non-CpG sites.

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(Via G3: Genes, Genomes, Genetics Mission - Online First Articles.)